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Ethanol Actions on the Ventral Tegmental Area: Novel Potential Targets on Reward Pathway Neurons
Abstract
The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Ethanol actions in the VTA may trigger neuroadaptation resulting in reduction of the aversive responses to alcohol and a relative increase in the rewarding responses. In searching for effective pharmacotherapies for the treatment of alcohol abuse and alcoholism, recognition of this imbalance may reveal novel strategies. In addition to conventional receptor/ion channel pharmacotherapies, epigenetic factors that control neuroadaptation to chronic ethanol treatment can be targeted as an avenue for development of therapeutic approaches to restore the balance. Furthermore, when exploring therapies to address reward/aversion imbalance in the action of alcohol in the VTA, sex differences have to be taken into account to ensure effective treatment for both men and women. These principles apply to a VTA-centric approach to therapies, but should hold true when thinking about the overall approach in the development of neuroactive drugs to treat alcohol use disorders. Although the functions of the VTA itself are complex, it is a useful model system to evaluate the reward/aversion imbalance that occurs with ethanol exposure and could be used to provide new leads in the efforts to develop novel drugs to treat alcoholism.
پیشرفت تحصیلی پایین می تواند منجر به اختلالات مصرف مواد در اواخر زندگی
یک مطالعه اخیر نشان داده است که پیشرفت تحصیلی ضعیف می تواند به اختلالات مصرف مواد در اواخر زندگی منجر شود. اطلاعات جمع آوری شده از شرکت کنندگان سوئدی در طول یک دوره 15 تا 20 ساله نشان دهنده ارتباط قوی بین پیشرفت تحصیلی پایین و سوء مصرف...
Mechanisms of Neuroimmune Gene Induction in Alcoholism
Abstract
Rationale
Alcoholism is a primary, chronic relapsing disease of brain reward, motivation, memory, and related circuitry. It is characterized by an individual’s continued drinking despite negative consequences related to alcohol...
Emergency Department Screening and Interventions for Substance Use Disorders
Abstract
The emergency department (ED) has long been recognized as providing critical access to the health care system for many, yet only in the past few decades has the ED visit been recognized as an opportunity to identify and link...
SAMHSA’s 2017 National Survey on Drug Use and Health
The National Survey on Drug Use and Health (NSDUH) is the most comprehensive survey of substance use, substance use disorders, mental health and the receipt of treatment services for these disorders in the United States. NSDUH began in 1971...
Summer Advanced Certificate Program in Media Based Prevention Science-Report of Pilot Program, Part 1
The Advanced Certificate Program in Media-Based Prevention was conducted at Claremont Graduate University from July 25, 2018 to August 14, 2018.
موانع درمان اعتیاد در میان بزرگسالانی که قبلاً در زندان بودند و اختلالات مصرف مواد داشتند
آبستره
سابقه و هدف
درمان اعتیاد مصرف مواد و نتایج تکرار جرم در میان افراد درگیر عدالت با اختلالات مصرف مواد را بهبود می بخشد، اما مورد استفاده قرار نمی گیرد. اگرچه اطلاعات در مورد موانع درمان اعتیاد در میان افراد مبتلا به اختلالات مصرف...
Mortality in the United States from Self-Injury Surpasses Diabetes: A Prevention Imperative
Abstract
This report uses an enhanced conceptualisation of self-injury mortality (SIM), which comprised registered or known suicides by any method and estimated non-suicide deaths from opioid and other drug self-intoxication. SIM surpassed...
Mind the Gap: Putting Evidence into Practice in the Era of Learning Health Systems
Due to the increasing amount of available published evidence and the continual need to apply and update evidence in practice, we propose a shift in the way evidence generated by learning health systems can be integrated into more traditional evidence reviews.
La incapacidad temporal atribuible al consumo de tabaco en trabajadores de 35-64 años
RESUMEN
Fundamentos: Pocos estudios recientes han investigado en nuestro medio la magnitud y las tendencias del impacto del consumo de tabaco en la pérdida de productividad. El objetivo de este trabajo fue describir la proporción de...
Sexual Behaviour and Abuse of Drugs among Urban Teenagers in Lagos
Sexual Behaviour and Abuse of Drugs Among Urban Teenagers in Lagos
Molobe Ikenna Daniel 1, 2, 3, 4
1 Unified Initiative for a Drug-Free Nigeria, Lagos, Nigeria
2 World Federation Against Drugs (WFAD), Stockholm, Sweden
3 Foundation for...
آگاهی، نگرش و عملکرد سوء مصرف مواد مخدر در میان مردان و زنان ورزشی در ایالت لاگوس نایجریا
آگاهی، نگرش و عملکرد سوء مصرف مواد مخدر در میان مردان و زنان ورزشی در ایالت لاگوس نایجریا
مولوب، ایکنا دانیل
معاون برنامه ها، ابتکار متحد برای یک نایجریا آزاد مواد مخدر (UIFDFN)
عضو فدراسیون جهانی مبارزه با مواد مخدر
دریافت فوریه 07...
Drug Abuse and Unsafe Abortion among Teenage Girls in Nigeria
Ikenna Molobe
I. Molobe. Unified Initiative for a Drug-Free Nigeria, Nigeria
Methods: The study methodology adopted the use of qualitative and quantitative approach. Focus Group Discussions (FGD) were conducted among secondary school...
Effectiveness Bank Matrix Cell: Reconciling the Interests of Community, Clients, and Families
Key studies on the roles of management in treatment’s impacts on crime and safeguarding the community, with a focus on criminal justice and child protection. Explore what research can offer managers who have to reconcile the interests of...
UAE to Train Specialist Drug Counsellors to Treat Rising Number of Abuse Cases
The UAE's National Rehabilitation Centre is opening a training center which will disseminate training programs, including the Universal Treatment Curriculum (UTC) for the Middle East region.
راهنمای مرجع سریع: درمان استفاده از دخانیات و وابستگی
این راهنمای بالینی روند توسعه، تجزیه و تحلیل و بحث از تحقیقات موجود در حالی که ارائه اطلاعات کامل تر برای تصمیم گیری مراقبت های بهداشتی را توصیف می کند.
The Effect of Public Health-Oriented Drug Law Reform on HIV Incidence in People who Inject Drugs in Tijuana, Mexico
Summary
Background
As countries embark on public health-oriented drug law reform, health impact evaluations are needed. In 2012, Mexico mandated the narcomenudeo reform, which depenalised the possession of small amounts of drugs and...
Mr. Ahmad Shah Nominated for the Prestigious "Asia Inspiration Award 2018"
Mr. Ahmad Shah, Director of ISSUP Pakistan, has been nominated to receive the prestigious "Asia Inspiration Award 2018" in the category of Health. The award ceremony will be held on 30th November 2018 in Iconic BMICH, Colombo, Sri Lanka dur...
