Cerca

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Stephen S. Kulis Arizona State University

Flavio F. Marsiglia Arizona State University; B...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Alyssa Banford Witting Brigham Young University

Jessica Lambert California State University...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Gillian England-Mason McMaster University

Andrea Gonzalez McMaster University; Leslie...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Muhammad Armaghan Mussadiq University of Maryland at College Park

Bradley Owen Boekeloo...

Abstract The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Ethanol actions in the VTA may trigger neuroadaptation resulting in reduction of the aversive responses to alcohol and a relative increase in the rewarding responses. In searching for effective pharmacotherapies for the treatment of alcohol abuse and alcoholism, recognition of this imbalance may reveal novel strategies. In addition to conventional receptor/ion channel pharmacotherapies, epigenetic factors that control neuroadaptation to chronic ethanol treatment can be targeted as an avenue for development of therapeutic approaches to restore the balance. Furthermore, when exploring therapies to address reward/aversion imbalance in the action of alcohol in the VTA, sex differences have to be taken into account to ensure effective treatment for both men and women. These principles apply to a VTA-centric approach to therapies, but should hold true when thinking about the overall approach in the development of neuroactive drugs to treat alcohol use disorders. Although the functions of the VTA itself are complex, it is a useful model system to evaluate the reward/aversion imbalance that occurs with ethanol exposure and could be used to provide new leads in the efforts to develop novel drugs to treat alcoholism.

RESUMEN

Fundamentos: Pocos estudios recientes han investigado en nuestro medio la magnitud y las tendencias del impacto del con­sumo de tabaco en la pérdida de productividad. El objetivo de este trabajo fue describir la proporción de...

Conoscenza, atteggiamento e pratica sull'abuso di droga tra gli sportivi nello stato di Lagos, Nigeria

Molobe, Daniele Ikenna

Vicedirettore dei programmi, Iniziativa unificata per una Nigeria libera dalla droga (UIFDFN)

Membro della...

ASTRATTO
Introduzione: Il disturbo del gioco d'azzardo è caratterizzato da un bisogno incontrollabile di giocare, mancanza di controllo sul gioco d'azzardo, dando priorità al gioco d'azzardo rispetto ad altre attività e continuando a giocare...

Punti chiave

Domanda: I cambiamenti nel consumo di alcol e tabacco a livello di popolazione sono associati a cambiamenti nella mortalità complessiva per cancro?

Risultati: In questo studio di coorte basato sulla popolazione, le...

Abstract

Objectives: This study evaluated breath carbon monoxide (BCO) testing in identifying maternal smokers as well as the difference between disclosers and non-disclosers of smoking status. We also investigated if other extrinsic...

La marihuana es la sustancia ilegal más usada, pero crece consumo de ‘popper’.

Al menos 520 mil estudiantes de colegio, cuyas edades están entre los 12 y los 18 años, han consumido drogas por lo menos una vez en su vida. Esa cifra...

Abstract

Background: Binge drinking prevalence rates are highest in young adults; however, little is known about the effects of binge drinking on blood pressure (BP) and other cardiovascular health metrics in individuals between 18 and 45...

Astratto

Sfondo: Sebbene sia ben noto che il consumo di alcol pesante aumenta il rischio di ipertensione, il rischio associato a bassi livelli di assunzione di alcol negli uomini e nelle donne non è chiaro.

Metodi e risultati: Abbiamo...

Il World Drug Report 2018 è stato lanciato il 26 giugno. La relazione copre una serie di argomenti con gli opuscoli suddivisi in domanda e offerta di droga, mercati della droga, droga ed età, donne e droghe. 

Gli opuscoli sono tutti...

The 2018 theme of the United Nation's Office on Drugs and Crime was "Listen First".

The 26th of June marks the International Day Against Drug Abuse and Illicit Trafficking.

Hanover Hospital and its affiliated healthcare clinics has become a model for how a healthcare system that is fully engaged in embracing evidence-based treatment of opioid use disorders can make significant change.

A little more than a...

Sebbene il binge drinking sia in aumento nelle donne in età riproduttiva e durante la gravidanza, le conseguenze nella prole, in particolare l'ereditarietà dei disturbi dell'umore legati all'alcol e la vulnerabilità all'abuso di alcol, sono...