This meta-analysis reviewed 55 longitudinal studies involving more than 540,000 participants to examine the relationship between spirituality and harmful or hazardous alcohol and other drug use. The findings show that spiritual and religious involvement is associated with a 13% reduction in the risk of substance use and related harms, with even stronger protective effects among individuals who regularly participate in religious communities.

The protective association was observed across alcohol, tobacco, cannabis, and other illicit drugs, and was linked to both prevention of substance use and...