Cerca

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Stephen S. Kulis Arizona State University

Flavio F. Marsiglia Arizona State University; B...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Puja Patel Duke University

Eve S. Puffer Duke University

Introduction: Substance use...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Deinera Exner-Cortens University of Calgary 

Debb Hurlock Creative Theory Inc.; Pam Krause ...

Abstract The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Ethanol actions in the VTA may trigger neuroadaptation resulting in reduction of the aversive responses to alcohol and a relative increase in the rewarding responses. In searching for effective pharmacotherapies for the treatment of alcohol abuse and alcoholism, recognition of this imbalance may reveal novel strategies. In addition to conventional receptor/ion channel pharmacotherapies, epigenetic factors that control neuroadaptation to chronic ethanol treatment can be targeted as an avenue for development of therapeutic approaches to restore the balance. Furthermore, when exploring therapies to address reward/aversion imbalance in the action of alcohol in the VTA, sex differences have to be taken into account to ensure effective treatment for both men and women. These principles apply to a VTA-centric approach to therapies, but should hold true when thinking about the overall approach in the development of neuroactive drugs to treat alcohol use disorders. Although the functions of the VTA itself are complex, it is a useful model system to evaluate the reward/aversion imbalance that occurs with ethanol exposure and could be used to provide new leads in the efforts to develop novel drugs to treat alcoholism.

RESUMEN

Fundamentos: Pocos estudios recientes han investigado en nuestro medio la magnitud y las tendencias del impacto del con­sumo de tabaco en la pérdida de productividad. El objetivo de este trabajo fue describir la proporción de...

Conoscenza, atteggiamento e pratica sull'abuso di droga tra gli sportivi nello stato di Lagos, Nigeria

Molobe, Daniele Ikenna

Vicedirettore dei programmi, Iniziativa unificata per una Nigeria libera dalla droga (UIFDFN)

Membro della...

ASTRATTO
Introduzione: Il disturbo del gioco d'azzardo è caratterizzato da un bisogno incontrollabile di giocare, mancanza di controllo sul gioco d'azzardo, dando priorità al gioco d'azzardo rispetto ad altre attività e continuando a giocare...

Punti chiave

Domanda: I cambiamenti nel consumo di alcol e tabacco a livello di popolazione sono associati a cambiamenti nella mortalità complessiva per cancro?

Risultati: In questo studio di coorte basato sulla popolazione, le...

La marihuana es la sustancia ilegal más usada, pero crece consumo de ‘popper’.

Al menos 520 mil estudiantes de colegio, cuyas edades están entre los 12 y los 18 años, han consumido drogas por lo menos una vez en su vida. Esa cifra...

Abstract

Background: Binge drinking prevalence rates are highest in young adults; however, little is known about the effects of binge drinking on blood pressure (BP) and other cardiovascular health metrics in individuals between 18 and 45...

Astratto

Sfondo: Sebbene sia ben noto che il consumo di alcol pesante aumenta il rischio di ipertensione, il rischio associato a bassi livelli di assunzione di alcol negli uomini e nelle donne non è chiaro.

Metodi e risultati: Abbiamo...

È passato un decennio da quando la crisi finanziaria ha fatto salire il tasso di disoccupazione negli Stati Uniti e ha costretto le persone nel pieno della loro carriera a rinunciare a cercare lavoro.

Ancora oggi, mentre i datori di lavoro...

RESUMEN

Introducción: Las personas que consumen heroína y cocaína presentan una mayor actividad sexual, conductas de riesgo relacionadas con la inyección y un uso inconsistente del condón, lo que aumentaría el riesgo de infecciones de...

Abstract

Objectives: Secondhand smoke (SHS) exposure is associated with cardiovascular disease. This study aims to determine the association between SHS exposure estimated by questionnaire and hypertension in Korean never smokers.

Setting...

Scotland has become the first country in the world to enforce a minimum price per unit of alcohol. As of 1 May 2018 all alcohol must cost no less than 0.5GPD or 50 pence. 

The move is the result of a long process of research and...

Abstract

Introduction: Marijuana is the world’s most widely used illegal drug. In Mexico, it is the drug of choice for both male and female users of all ages, and there has been a recent increase in its use. 

Objective: To describe drug...

Questo interessante testo è il prodotto della collaborazione tra l'Istituto di cura e prevenzione delle dipendenze (IAPA) e l'Istituto nazionale di psichiatria Ramón de la Fuente Muñiz (INFRDM), istituzioni che condividono l'impegno a...