Search

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Stephen S. Kulis Arizona State University

Flavio F. Marsiglia Arizona State University; B...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Puja Patel Duke University

Eve S. Puffer Duke University

Introduction: Substance use...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Deinera Exner-Cortens University of Calgary 

Debb Hurlock Creative Theory Inc.; Pam Krause ...

Abstract The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Ethanol actions in the VTA may trigger neuroadaptation resulting in reduction of the aversive responses to alcohol and a relative increase in the rewarding responses. In searching for effective pharmacotherapies for the treatment of alcohol abuse and alcoholism, recognition of this imbalance may reveal novel strategies. In addition to conventional receptor/ion channel pharmacotherapies, epigenetic factors that control neuroadaptation to chronic ethanol treatment can be targeted as an avenue for development of therapeutic approaches to restore the balance. Furthermore, when exploring therapies to address reward/aversion imbalance in the action of alcohol in the VTA, sex differences have to be taken into account to ensure effective treatment for both men and women. These principles apply to a VTA-centric approach to therapies, but should hold true when thinking about the overall approach in the development of neuroactive drugs to treat alcohol use disorders. Although the functions of the VTA itself are complex, it is a useful model system to evaluate the reward/aversion imbalance that occurs with ethanol exposure and could be used to provide new leads in the efforts to develop novel drugs to treat alcoholism.

OVERVIEW

Fundamentals: Few recent studies have investigated in our half the magnitude and trends of the impact of tobacco in lost productivity. The objective of this study was to describe the proportion of episodes and days in non...

Knowledge, Attitude and Practice on Drug Abuse among Sports Men and Women in Lagos State, Nigeria

Molobe, Ikenna Daniel

Deputy Director of Programs, Unified Initiative for a Drug Free Nigeria (UIFDFN)

Member, World Federation Against...

ABSTRACT
Introduction: Gambling disorder is characterized by an uncontrollable need to gamble, lack of control over gambling, prioritizing gambling over other activities, and continuing to gamble despite the negative consequences this...

Key Points

Question: Are changes in population-level alcohol and tobacco consumption associated with changes in overall cancer mortality?

Findings: In this population-based cohort study, temporal associations of alcohol and tobacco...

Marijuana is the most widely used illegal substance, but growing consumption of 'popper'.

At least 520 thousand high school students, whose ages are between 12 and 18, have used drugs at least once in your life. That figure represents 15.9...

Abstract

Background: Binge drinking prevalence rates are highest in young adults; however, little is known about the effects of binge drinking on blood pressure (BP) and other cardiovascular health metrics in individuals between 18 and 45...

Abstract

Background: Although it is well established that heavy alcohol consumption increases the risk of hypertension, the risk associated with low levels of alcohol intake in men and women is unclear.

Methods and Results: We searched...

It's been a decade since the financial crisis drove up the unemployment rate in the U.S. and forced people in the prime of their careers to give up looking for work.

Even today, as employers add jobs at a furious pace, the workforce...

OVERVIEW

Introduction: People who consume heroin and cocaine have increased sexual activity, risk behaviours associated with injection and inconsistent condom use, which would increase the risk of sexually transmitted infections and the...

Abstract

Objectives: Secondhand smoke (SHS) exposure is associated with cardiovascular disease. This study aims to determine the association between SHS exposure estimated by questionnaire and hypertension in Korean never smokers.

Setting...

Scotland has become the first country in the world to enforce a minimum price per unit of alcohol. As of 1 May 2018 all alcohol must cost no less than 0.5GPD or 50 pence. 

The move is the result of a long process of research and...

Abstract

Introduction: Marijuana is the world’s most widely used illegal drug. In Mexico, it is the drug of choice for both male and female users of all ages, and there has been a recent increase in its use. 

Objective: To describe drug...

This interesting text is the product of collaboration between the Institute of care and prevention of addictions (IAPA) and the National Institute of Psychiatry Ramón de la Fuente Muñiz (INFRDM), institutions that share the commitment to...