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Supply and market disruption refers to coordinated strategies aimed at reducing the production, trafficking, distribution, and availability of illicit substances. These strategies often involve law enforcement, regulatory controls, border management, and financial investigations designed to disrupt drug trafficking networks and weaken illicit drug markets. By targeting supply chains and market dynamics, these efforts aim to reduce the availability of drugs, increase the risks and costs associated with illegal production and distribution, and contribute to broader efforts to reduce substance-related harms. Effective supply and market disruption typically operates alongside public health, prevention, treatment, and recovery responses as part of a comprehensive approach to substance use.