جستجو

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Stephen S. Kulis Arizona State University

Flavio F. Marsiglia Arizona State University; B...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Puja Patel Duke University

Eve S. Puffer Duke University

Introduction: Substance use...

این مقاله در نشست سالانه انجمن تحقیقات پیشگیری 2018 که 29 می – 1 جون 2018 در واشنگتن دی سی آمریکا برگزار شد، ارائه شد.

دانشگاه دینر-کورتنز کلگری 

دب هرلوک خلاق تئوری شرکت ;  مرکز بهداشت جنسی پم کراوس کلگری

توجه فزاینده به نقش مردان و...

Abstract The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Ethanol actions in the VTA may trigger neuroadaptation resulting in reduction of the aversive responses to alcohol and a relative increase in the rewarding responses. In searching for effective pharmacotherapies for the treatment of alcohol abuse and alcoholism, recognition of this imbalance may reveal novel strategies. In addition to conventional receptor/ion channel pharmacotherapies, epigenetic factors that control neuroadaptation to chronic ethanol treatment can be targeted as an avenue for development of therapeutic approaches to restore the balance. Furthermore, when exploring therapies to address reward/aversion imbalance in the action of alcohol in the VTA, sex differences have to be taken into account to ensure effective treatment for both men and women. These principles apply to a VTA-centric approach to therapies, but should hold true when thinking about the overall approach in the development of neuroactive drugs to treat alcohol use disorders. Although the functions of the VTA itself are complex, it is a useful model system to evaluate the reward/aversion imbalance that occurs with ethanol exposure and could be used to provide new leads in the efforts to develop novel drugs to treat alcoholism.

RESUMEN

Fundamentos: Pocos estudios recientes han investigado en nuestro medio la magnitud y las tendencias del impacto del con­sumo de tabaco en la pérdida de productividad. El objetivo de este trabajo fue describir la proporción de...

آگاهی، نگرش و عملکرد سوء مصرف مواد مخدر در میان مردان و زنان ورزشی در ایالت لاگوس نایجریا

مولوب، ایکنا دانیل

معاون برنامه ها، ابتکار متحد برای یک نایجریا آزاد مواد مخدر (UIFDFN)

عضو فدراسیون جهانی مبارزه با مواد مخدر

دریافت فوریه 07...

آبستره
مقدمه: اختلال قمار با نياز غير قابل کنترل به قمار، عدم کنترل بر قمار، اولويت بندی قمار بر فعاليت های ديگر و ادامه قمار با وجود عواقب منفی که در پی دارد، مشخص می شود. در سراسر جهان، بین 1.1٪ و 5٪ از مردم نشان می دهد نشانه هایی از قمار...

Key Points

Question: Are changes in population-level alcohol and tobacco consumption associated with changes in overall cancer mortality?

Findings: In this population-based cohort study, temporal associations of alcohol and tobacco...

La marihuana es la sustancia ilegal más usada, pero crece consumo de ‘popper’.

Al menos 520 mil estudiantes de colegio, cuyas edades están entre los 12 y los 18 años, han consumido drogas por lo menos una vez en su vida. Esa cifra...

Abstract

Background: Binge drinking prevalence rates are highest in young adults; however, little is known about the effects of binge drinking on blood pressure (BP) and other cardiovascular health metrics in individuals between 18 and 45...

آبستره

سابقه و هدف: با وجودی که به خوبی ثابت شده است که مصرف الکل سنگین خطر فشار خون بالا را افزایش می دهد، خطر مرتبط با سطوح پایین مصرف الکل در مردان و زنان نامشخص است.

روش ها و نتايج: ما مدلاین و امباس را برای مطالعات هم گروه اصلی در...

It's been a decade since the financial crisis drove up the unemployment rate in the U.S. and forced people in the prime of their careers to give up looking for work.

Even today, as employers add jobs at a furious pace, the workforce...

RESUMEN

Introducción: Las personas que consumen heroína y cocaína presentan una mayor actividad sexual, conductas de riesgo relacionadas con la inyección y un uso inconsistente del condón, lo que aumentaría el riesgo de infecciones de...

Abstract

Objectives: Secondhand smoke (SHS) exposure is associated with cardiovascular disease. This study aims to determine the association between SHS exposure estimated by questionnaire and hypertension in Korean never smokers.

Setting...

Scotland has become the first country in the world to enforce a minimum price per unit of alcohol. As of 1 May 2018 all alcohol must cost no less than 0.5GPD or 50 pence. 

The move is the result of a long process of research and...

Abstract

Introduction: Marijuana is the world’s most widely used illegal drug. In Mexico, it is the drug of choice for both male and female users of all ages, and there has been a recent increase in its use. 

Objective: To describe drug...

این متن جالب محصول همکاری بین موسسه مراقبت و پیشگیری از اعتیاد (IAPA) و موسسه ملی روانپزشکی رامون د لا فوئنته مونیز (INFRDM)، موسساتی که تعهد تولید دانش در مورد مشکلات مرتبط با نابرابری، شرایط زندگی جمعیت بومی و مصرف مواد روانگردان را به...