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Psychoactive Substances
Psychoactive substances are natural or synthetic substances that act on the central nervous system and alter mental processes such as mood, perception, cognition, consciousness, and behaviour. These substances may be legally prescribed medications (e.g., pain medications or sedatives), legally available substances such as alcohol or caffeine, or controlled or illicit drugs. Psychoactive substances can be used for medical, social, cultural, or recreational purposes, but some carry risks of misuse, dependence, and health or social harms when used in harmful ways.
Challenges Treating Drug Abuse and Addiction with Co Occurring Disorders in Nairobi and Kiambu.
Challenges Treating Drug Abuse and Addiction with Co‑Occurring Disorders in Nairobi and Kiambu.
Prepared by: Kelvin Ateko, Mental Health Nurse
Setting: Urban outpatient/inpatient mental health and addiction services in Nairob ans Kiambu i...
Annual Report to the Parliament on Drug Addictions in Italy
The 2025 Annual Report to the Parliament on Drug Addictions in Italy offers a comprehensive overview of the current drug addiction landscape. Despite a slight decline in youth drug use for the first time since 2018, the report highlights...
lmplementing MyAIM™ as a Smartphone-based App Intervention for Youth Stimulant Use in a Middle-Income Country: Challenges and Proposed Solutions
Prevalence of Psilocybin Use in Vaping and Associated Factors: A Study among Amphetamine-type Stimulants (ATS) Use Disorder in Malaysia
Clinical and Neurophysiological Evaluation of qEEG-Guided Transcranial Magnetic Stimulation (TMS) Therapy in Methamphetamine Dependence: A Case Series Report at the National Narcotics Board Rehabilitation Center of the Republic of Indonesia
Strengthening the Backbone of Drug Treatment: Advancing Quality Standards for Addiction Counselors in Indonesia
Combat Drug Abuse and Trafficking in Indonesian High-Risk Areas
ISSUP Nigeria Knowledge Update Series (28th Session): Trauma and Substance Use: Understanding the Connection and Promoting Trauma-Informed Prevention in Nigeria
World Drug Report 2025: Key Trends and Policy Challenges for Africa
Analyzing 10 Years of Drug Use Trends and Transforming Addiction Care Beyond Rehabilitation
Substance and Drug consumption in schools
ABSTRACT
INTRODUCTION
In 2012, about 3.3 million net deaths, or 5.9% of all global deaths, were attributable to alcohol consumption. There are significant sex differences in the proportion of global deaths attributable to alcohol, for...
Massive Study Flips Our Story of Addiction and the Brain
A large U.S. study has found that some children and teens who start using alcohol, cannabis, or nicotine at an early age already show differences in their brains before they ever try any substance. This challenges the common belief that...
New Psychoactive Substances: Studies from Central Asia and China
Recommended Reading: New Psychoactive Substances: Studies from Central Asia and China
We are pleased to present the book "New Psychoactive Substances: Studies from Central Asia and China", prepared by an international team of experts and...
A Deeper Look into the Roots of Substance Use Disorders
Addiction is often seen through the lens of poor choices or lack of willpower, but this view oversimplifies what is, in reality, a highly complex mental health condition. Through my academic journey in addiction counseling, I’ve come to...
A Deeper Look into the Roots of Substance Use Disorders
Addiction is often seen through the lens of poor choices or lack of willpower, but this view oversimplifies what is, in reality, a highly complex mental health condition. Through my academic journey in addiction counseling, I’ve come to...
World Drug Report 2025
On July 2nd, 2025, ISSUP had the privilege of hosting a webinar outlining highlights from the 2025 edition of the World Drug Report (WDR), presented by Ms. Giovanna Campello, Chief of the Prevention, Treatment and Rehabilitation Section at...
Mindfulness treatment for substance misuse: A systematic review and meta-analysis.
Highlights
•First meta-analysis of mindfulness treatment for substance misuse.
•Mindfulness treatment is a positive intervention for substance use disorders.
•Mindfulness treatment had a significant small effect on reducing substance...
Anger and substance abuse: a systematic review and meta-analysis.
ABSTRACT
Objective: Conduct a systematic review and meta-analysis to evaluate levels of anger among substance users compared to non-user controls and to analyze the possible association between anger and psychoactive substance use (PSU).
...Posttraumatic Stress Disorder Among Opioid Users in Dodoma, Tanzania: A Comparative Cross-Sectional Study Protocol
INTRODUCTION:
Post traumatic stress disorder (PTSD) is highly commorbid among individuals with opioid use disorder (OUD). PTSD among people with OUD is associated with severe opioid use, depression, and suicidality. Tanzania has seen a...
Criminal reactions to drug-using offenders: A systematic review of the effect of treatment and/or punishment on reduction of drug use and/or criminal recidivism
The association between substance use and crime is very common, but complex. Several countries have found strategies to face drug abuse and criminality that may exist associated to it, seeking to reduce overcrowded prisons and to promote...
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