Hledat

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Stephen S. Kulis Arizona State University

Flavio F. Marsiglia Arizona State University; B...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Alyssa Banford Witting Brigham Young University

Jessica Lambert California State University...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Gillian England-Mason McMaster University

Andrea Gonzalez McMaster University; Leslie...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Muhammad Armaghan Mussadiq University of Maryland at College Park

Bradley Owen Boekeloo...

Abstract The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Ethanol actions in the VTA may trigger neuroadaptation resulting in reduction of the aversive responses to alcohol and a relative increase in the rewarding responses. In searching for effective pharmacotherapies for the treatment of alcohol abuse and alcoholism, recognition of this imbalance may reveal novel strategies. In addition to conventional receptor/ion channel pharmacotherapies, epigenetic factors that control neuroadaptation to chronic ethanol treatment can be targeted as an avenue for development of therapeutic approaches to restore the balance. Furthermore, when exploring therapies to address reward/aversion imbalance in the action of alcohol in the VTA, sex differences have to be taken into account to ensure effective treatment for both men and women. These principles apply to a VTA-centric approach to therapies, but should hold true when thinking about the overall approach in the development of neuroactive drugs to treat alcohol use disorders. Although the functions of the VTA itself are complex, it is a useful model system to evaluate the reward/aversion imbalance that occurs with ethanol exposure and could be used to provide new leads in the efforts to develop novel drugs to treat alcoholism.

RESUMEN

Fundamentos: Pocos estudios recientes han investigado en nuestro medio la magnitud y las tendencias del impacto del con­sumo de tabaco en la pérdida de productividad. El objetivo de este trabajo fue describir la proporción de...

Knowledge, Attitude and Practice on Drug Abuse among Sports Men and Women in Lagos State, Nigeria

Molobe, Ikenna Daniel

Deputy Director of Programs, Unified Initiative for a Drug Free Nigeria (UIFDFN)

Member, World Federation Against...

ABSTRAKTNÍ
Úvod: Porucha hazardních her je charakterizována nekontrolovatelnou potřebou hazardu, nedostatkem kontroly nad hazardními hrami, upřednostňováním hazardních her před jinými činnostmi a pokračováním v hazardních hrách navzdory...

Key Points

Question: Are changes in population-level alcohol and tobacco consumption associated with changes in overall cancer mortality?

Findings: In this population-based cohort study, temporal associations of alcohol and tobacco...

Abstract

Objectives: This study evaluated breath carbon monoxide (BCO) testing in identifying maternal smokers as well as the difference between disclosers and non-disclosers of smoking status. We also investigated if other extrinsic...

La marihuana es la sustancia ilegal más usada, pero crece consumo de ‘popper’.

Al menos 520 mil estudiantes de colegio, cuyas edades están entre los 12 y los 18 años, han consumido drogas por lo menos una vez en su vida. Esa cifra...

Abstraktní

Pozadí: Míra prevalence nárazového pití je nejvyšší u mladých dospělých; o účincích nárazového pití na krevní tlak (TK) a další ukazatele kardiovaskulárního zdraví u jedinců ve věku 18 až 45 let je však známo jen málo. Cílem...

Abstract

Background: Although it is well established that heavy alcohol consumption increases the risk of hypertension, the risk associated with low levels of alcohol intake in men and women is unclear.

Methods and Results: We searched...

The 2018 World Drug Report was launched on 26th June. The report covers a range of topics with the booklets split into drug demand and supply, drug markets, drugs and age, and women and drugs. 

The booklets are all available free to access...

Tématem Úřadu OSN pro drogy a kriminalitu v roce 2018 bylo "Listen First".

26. červen je Mezinárodním dnem boje proti zneužívání drog a nezákonnému obchodování.

Hanover Hospital and its affiliated healthcare clinics has become a model for how a healthcare system that is fully engaged in embracing evidence-based treatment of opioid use disorders can make significant change.

A little more than a...

Although binge drinking is on the rise in women of reproductive age and during pregnancy, the consequences in the offspring, in particular the inheritance of alcohol-related mood disturbances and alcohol abuse vulnerability, are still...