Hledat

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Stephen S. Kulis Arizona State University

Flavio F. Marsiglia Arizona State University; B...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Puja Patel Duke University

Eve S. Puffer Duke University

Introduction: Substance use...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Deinera Exner-Cortens University of Calgary 

Debb Hurlock Creative Theory Inc.; Pam Krause ...

Abstract The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Ethanol actions in the VTA may trigger neuroadaptation resulting in reduction of the aversive responses to alcohol and a relative increase in the rewarding responses. In searching for effective pharmacotherapies for the treatment of alcohol abuse and alcoholism, recognition of this imbalance may reveal novel strategies. In addition to conventional receptor/ion channel pharmacotherapies, epigenetic factors that control neuroadaptation to chronic ethanol treatment can be targeted as an avenue for development of therapeutic approaches to restore the balance. Furthermore, when exploring therapies to address reward/aversion imbalance in the action of alcohol in the VTA, sex differences have to be taken into account to ensure effective treatment for both men and women. These principles apply to a VTA-centric approach to therapies, but should hold true when thinking about the overall approach in the development of neuroactive drugs to treat alcohol use disorders. Although the functions of the VTA itself are complex, it is a useful model system to evaluate the reward/aversion imbalance that occurs with ethanol exposure and could be used to provide new leads in the efforts to develop novel drugs to treat alcoholism.

RESUMEN

Fundamentos: Pocos estudios recientes han investigado en nuestro medio la magnitud y las tendencias del impacto del con­sumo de tabaco en la pérdida de productividad. El objetivo de este trabajo fue describir la proporción de...

Knowledge, Attitude and Practice on Drug Abuse among Sports Men and Women in Lagos State, Nigeria

Molobe, Ikenna Daniel

Deputy Director of Programs, Unified Initiative for a Drug Free Nigeria (UIFDFN)

Member, World Federation Against...

ABSTRAKTNÍ
Úvod: Porucha hazardních her je charakterizována nekontrolovatelnou potřebou hazardu, nedostatkem kontroly nad hazardními hrami, upřednostňováním hazardních her před jinými činnostmi a pokračováním v hazardních hrách navzdory...

Key Points

Question: Are changes in population-level alcohol and tobacco consumption associated with changes in overall cancer mortality?

Findings: In this population-based cohort study, temporal associations of alcohol and tobacco...

La marihuana es la sustancia ilegal más usada, pero crece consumo de ‘popper’.

Al menos 520 mil estudiantes de colegio, cuyas edades están entre los 12 y los 18 años, han consumido drogas por lo menos una vez en su vida. Esa cifra...

Abstraktní

Pozadí: Míra prevalence nárazového pití je nejvyšší u mladých dospělých; o účincích nárazového pití na krevní tlak (TK) a další ukazatele kardiovaskulárního zdraví u jedinců ve věku 18 až 45 let je však známo jen málo. Cílem...

Abstract

Background: Although it is well established that heavy alcohol consumption increases the risk of hypertension, the risk associated with low levels of alcohol intake in men and women is unclear.

Methods and Results: We searched...

Je to deset let, co finanční krize zvýšila míru nezaměstnanosti v USA a donutila lidi na vrcholu své kariéry, aby se vzdali hledání práce.

Dokonce i dnes, kdy zaměstnavatelé přidávají pracovní místa zběsilým tempem, se míra účasti pracovní...

RESUMEN

Introducción: Las personas que consumen heroína y cocaína presentan una mayor actividad sexual, conductas de riesgo relacionadas con la inyección y un uso inconsistente del condón, lo que aumentaría el riesgo de infecciones de...

Abstract

Objectives: Secondhand smoke (SHS) exposure is associated with cardiovascular disease. This study aims to determine the association between SHS exposure estimated by questionnaire and hypertension in Korean never smokers.

Setting...

Skotsko se stalo první zemí na světě, která zavedla minimální cenu za jednotku alkoholu. Od 1. května 2018 musí veškerý alkohol stát nejméně 0,5GPD nebo 50 pencí. 

Tento krok je výsledkem dlouhého procesu výzkumu a rozhovorů se skotským...

Abstract

Introduction: Marijuana is the world’s most widely used illegal drug. In Mexico, it is the drug of choice for both male and female users of all ages, and there has been a recent increase in its use. 

Objective: To describe drug...

Este interesante texto es producto de la colaboración entre el Instituto de Atención y Prevención de las Adicciones (IAPA) y el Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (INFRDM), instituciones que comparten el compromiso...