The emphasis of our research is on ‘what works’ in the prevention and treatment of substance misuse: the Addictions Department represents a network of clinicians, researchers and clinical teachers who have a shared commitment to excellence in prevention and treatment work, and to supporting and strengthening national and international endeavours in this field. Over the last 30 years, our staff have developed a body of research evidence that has informed the development of new treatment services for alcohol, smoking and drug problems in the UK.