Abstract

Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use disorder (SUD). Variants in the ADGRL3 (LPHN3) gene predispose to ADHD and predict ADHD severity, disruptive behaviors comorbidity, long-term outcome, and response to treatment. In this study, we investigated whether variants within ADGRL3 are associated with SUD, a disorder that is frequently co-morbid with ADHD. Using family-based, case-control, and longitudinal...

Gene-environment interactions occur when different surroundings make it more or less likely for a particular trait or disorder to develop.

The concept of ‘alcogenic’ environments describes features, such as alcohol outlet density or marketing, which influence patterns of alcohol consumption.

A recent study, which analysed longitudinal data of 18–26-year-olds, has examined the link between genetic variation in alcohol problems and the number of alcohol outlets in a community.

The results from the study found that:

• There was evidence to suggest that the extent of genetic and environmental...

Abstrak

Alasan

Alkoholisme adalah penyakit kambuh kronis utama dari penghargaan otak, motivasi, memori, dan sirkuit terkait. Hal ini ditandai dengan individu terus minum meskipun konsekuensi negatif terkait dengan penggunaan alkohol, yang dicontohkan oleh penggunaan alkohol yang menyebabkan gangguan klinis yang signifikan atau tertekan. Konsumsi alkohol kronis meningkatkan ekspresi molekul sinyal imun bawaan (ISMs) di otak yang mengubah proses kognitif dan mempromosikan minum alkohol.

Tujuan

Mengungkap mekanisme induksi gen neuroimun yang diinduksi alkohol diperumit oleh loop positif dari...