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Genetics

Network is dedicated to discussing the genetics of substance use dependence.

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Anja Busse
UNODC

Members

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Jose Luis Vazquez Martinez

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Jose Luis Vazquez Martinez - 23 March 2023
Source: https://www.nature.com/articles/s44220-023-00034-y Abstract Genetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a multivariate genome-wide association meta-analysis that disaggregates general and substance...
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Jose Luis Vazquez Martinez

Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure

Jose Luis Vazquez Martinez - 3 December 2022
Source: Bohnsack, J. P., Zhang, H., Wandling, G. M., He, D., Kyzar, E. J., Lasek, A. W., & Pandey, S. C. (2022). Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure. Science advances, 8(18), eabn2748. Abstract Adolescent binge drinking is a...
Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure.pdf
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Jose Luis Vazquez Martinez

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

Jose Luis Vazquez Martinez - 21 September 2022
Source: Pasman, J. A., Verweij, K., Gerring, Z., Stringer, S., Sanchez-Roige, S., Treur, J. L., Abdellaoui, A., Nivard, M. G., Baselmans, B., Ong, J. S., Ip, H. F., van der Zee, M. D., Bartels, M., Day, F. R., Fontanillas, P., Elson, S. L., 23andMe Research Team, de Wit, H., Davis, L. K., MacKillop...
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Jose Luis Vazquez Martinez

Reflexiones sobre epigenética, confinamiento, violencia y estrés en niños, niñas y adolescentes durante la pandemia por COVID-19

Jose Luis Vazquez Martinez - 15 September 2022
Fuente: Marín-Navarrete, R., Templos-Núñez, L., & Nicolini, H. (2022). Reflexiones sobre epigenética, confinamiento, violencia y estrés en niños, niñas y adolescentes durante la pandemia por COVID-19. Revista inteRnacional de investigación en adicciones, 8(2), 3-6. Los últimos dos años han...
Reflexiones sobre epigenética, confinamiento, violencia y estrés en niños, niñas y adolescentes durante la pandemia por COVID-19.pdf
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Jose Luis Vazquez Martinez

Factores genéticos y adicciones - Dra. Alejandra Ruíz

Jose Luis Vazquez Martinez - 17 June 2022
¿Cuántos genes influyen para que una persona desarrolle una adicción? ¿Sabemos cuáles son estos genes? ¿Existen genes que determinan la adicción a ciertas substancias? Estas y otras preguntas serán respondidas por la Dra. Alejandra Ruiz, investigadora de la UNAM.
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Jose Luis Vazquez Martinez

Una mirada a la genética y epigenética en adicción a sustancias

Jose Luis Vazquez Martinez - 30 March 2022
Source: Sánchez Huesca R, Templos Núñez LB. A look at genetics and epigenetics in substance addiction. RIIAD [Internet]. 2022 Mar. 29 [cited 2022 Mar. 29];8(1):51-6. Available from: https://riiad.org/index.php/riiad/article/view/riiad-2022-1-06 Resumen Los trastornos por consumo de sustancias...
Una mirada a la genética y epigenética en adicción a sustancias.pdf
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Jose Luis Vazquez Martinez

Association of Genome-Wide Polygenic Scores for Multiple Psychiatric and Common Traits in Preadolescent Youths at Risk of Suicide

Jose Luis Vazquez Martinez - 1 March 2022
Source: Joo YY, Moon S, Wang H, et al. Association of Genome-Wide Polygenic Scores for Multiple Psychiatric and Common Traits in Preadolescent Youths at Risk of Suicide. JAMA Netw Open. 2022;5(2):e2148585. doi:10.1001/jamanetworkopen.2021.48585 Key Points Question Are genome-wide polygenic scores...
Association of Genome-Wide Polygenic Scores for Multiple Psychiatric and Common Traits in Preadolescent Youths at Risk of Suicide.pdf
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Jose Luis Vazquez Martinez

Allele-dosage genetic polymorphisms of cannabinoid receptor 1 predict attention, but not working memory performance in humans

Jose Luis Vazquez Martinez - 17 February 2022
Source: Ortega-Mora, E. I., Caballero-Sánchez, U., Román-López, T. V., Rosas-Escobar, C. B., González-Barrios, J. A., Romero-Hidalgo, S., ... & Ruiz-Contreras, A. E. (2021). Allele-dosage genetic polymorphisms of cannabinoid receptor 1 predict attention, but not working memory performance in humans...
Allele-dosage genetic polymorphisms of cannabinoid receptor 1 predict attention, but not working memory performance in humans.pdf
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Jose Luis Vazquez Martinez

Seminario de Investigación | Avances del proyecto ENCODAT-INMEGEN, de la epidemiología a la genómica

Jose Luis Vazquez Martinez - 23 November 2021
Humberto Nicolini, INMEGEN María Elena Medina-Mora, Facultad de Psicología, UNAM Jorge Ameth Villatoro Velázquez, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz" Marycarmen Noemí Bustos Gamiño, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz"
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Rasha Abi Hana

Association of genetic liability to smoking initiation with e-cigarette use in young adults: A cohort study

Shared by Rasha Abi Hana - 26 June 2021
Citation
Khouja JN, Wootton RE, Taylor AE, Davey Smith G, Munafò MR (2021) Association of genetic liability to smoking initiation with e-cigarette use in young adults: A cohort study. PLoS Med 18(3): e1003555.
Publication Date
2021

Background:

Tobacco smoking and e-cigarette use are strongly associated, but it is currently unclear whether this association is causal, or due to shared factors that influence both behaviours such as a shared genetic liability. The aim of this study was to investigate whether polygenic risk...

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Jose Luis Vazquez Martinez

Illicit drug use and the genetic overlap with Cannabis use

Jose Luis Vazquez Martinez - 23 July 2020
Source: Vink, J. M., Veul, L., Abdellaoui, A., Hottenga, J. J., Boomsma, D. I., & Verweij, K. J. (2020). Illicit Drug Use and the Genetic Overlap with Cannabis Use. Drug and Alcohol Dependence, 108102. Highlights •Lifetime prevalence: cannabis 24.8 %. •ecstacy 6.2 %, stimulants 6.5 % and any illicit...
Illicit drug use and the genetic overlap with Cannabis use.pdf
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Jose Luis Vazquez Martinez

Causal relationships between substance use and insomnia

Jose Luis Vazquez Martinez - 23 July 2020
Source: Pasman, J., Smit, D., Kingma, L., Vink, J., Treur, J., & Verweij, K. (2020, July 02). Causal relationships between substance use and insomnia. Retrieved from https://www.sciencedirect.com/science/article/pii/S0376871620303161 Highlights •Insomnia and substance use have been linked, but the...
Causal relationships between substance use and insomnia_0.pdf
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Jose Luis Vazquez Martinez

El cerebro, las drogas y los genes

Jose Luis Vazquez Martinez - 28 June 2020
Fuente: Ruiz Contreras, A., Méndez Díaz, M., Prieto Gómez, B., Romano, A., Caynas, S., & Prospéro García, O. (2010). El cerebro, las drogas y los genes. Salud Mental, 33(6), 535-542. Resumen En este segundo artículo sobre el tema reseñamos brevemente las drogas de abuso ilícitas. Describiremos...
El cerebro, las drogas y los genes.pdf
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Jose Luis Vazquez Martinez

Systemic Safety of a Recombinant AAV8 Vector for Human Cocaine Hydrolase Gene Therapy: A Good Laboratory Practice Preclinical Study in Mice

Jose Luis Vazquez Martinez - 16 January 2020
Source: Vicky Ping Chen, Yang Gao, Liyi Geng, Mike Steele, Nathan Jenks, Kah-Whye Peng, and Stephen Brimijoin.Human Gene Therapy.ahead of printhttp://doi.org/10.1089/hum.2019.233 Abstract Cocaine addiction continues to impose major burdens on affected individuals and broader society but is highly...
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Jose Luis Vazquez Martinez

Assessment of the Association of D2 Dopamine Receptor Gene and Reported Allele Frequencies With Alcohol Use Disorders A Systematic Review and Meta-analysis

Jose Luis Vazquez Martinez - 8 December 2019
Source: Jung Y, Montel RA, Shen P, Mash DC, Goldman D. Assessment of the Association of D2 Dopamine Receptor Gene and Reported Allele Frequencies With Alcohol Use Disorders: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(11):e1914940. doi:https://doi.org/10.1001/jamanetworkopen.2019...
Assessment of the Association of D2 Dopamine Receptor Gene and Reported Allele Frequencies With Alcohol Use Disorders A Systematic Review and Meta-analysis_1.pdf
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Ahmad Muneer Naser

Genetics and Epigenetics of Addiction

Ahmad Muneer Naser - 30 September 2019
Recent advances in DNA analysis are helping researchers untangle complex genetic interactions by examining a person's entire genome all at once. Technologies such as genome-wide association studies (GWAS)
genetics_and_epigenetics_drugfacts_2.pdf
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Jose Luis Vazquez Martinez

La vulnerabilidad genética al suicidio

Jose Luis Vazquez Martinez - 25 June 2019
Conferencia transmitida el día 12 de octubre de 2018. Los avances en la Genómica nos permiten atacar el entendimiento de diferentes conductas desde el nivel molecular. En esta conferencia veremos lo que ha descubierto la ciencia sobre las bases genéticas de los procesos mentales y cómo esto nos...
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Livia

Conventional and Genetic Evidence on Alcohol and Vascular Disease Aetiology: A Prospective Study of 500 000 Men and Women in China

Shared by Livia - 9 April 2019
Citation
Millwood, I. Y., Walters, R. G., Mei, X. W., Guo, Y., Yang, L., Bian, Z., ... & Zhou, G. (2019). Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China. The Lancet.
Publication Date
2019

Summary

Background

Moderate alcohol intake has been associated with reduced cardiovascular risk in many studies, in comparison with abstinence or with heavier drinking. Studies in east Asia can help determine whether these associations are causal, since two common genetic variants greatly...

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Livia

ADGRL3 (LPHN3) Variants Predict Substance Use Disorder

Shared by Livia - 28 March 2019
Citation
Arcos-Burgos, M., Vélez, J. I., Martinez, A. F., Ribasés, M., Ramos-Quiroga, J. A., Sánchez-Mora, C., ... & Casas, M. (2019). ADGRL3 (LPHN3) variants predict substance use disorder. Translational psychiatry, 9(1), 42.
Publication Date
2019

Abstract

Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use disorder (SUD). Variants in the ADGRL3 (LPHN3) gene predispose to...

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Jose Luis Vazquez Martinez

ADGRL3 (LPHN3) variants predict substance use disorder

Jose Luis Vazquez Martinez - 27 March 2019
Source: Arcos-Burgos, M., Vélez, J. I., Martinez, A. F., Ribasés, M., Ramos-Quiroga, J. A., Sánchez-Mora, C., ... & Casas, M. (2019). ADGRL3 (LPHN3) variants predict substance use disorder. Translational psychiatry, 9(1), 42. Abstract Genetic factors are strongly implicated in the susceptibility to...
ADGRL3 (LPHN3) variants predict substance use disorder.pdf
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