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Background: Traditional pharmacological and behavioral interventions for Substance Use Disorder (SUD) often struggle to address the persistent autonomic dysregulation and "allostatic load" that lead to relapse. Chronic substance use alters...

Recent United States alerts on fentanyl analogues, medetomidine, cychlorphine, drug mixtures and concentrated 7-OH products highlight evolving challenges across the substance use workforce. They invite us to review local preparedness, understand testing limitations and strengthen links between frontline services, laboratories and public-health partners. A useful response brings together clinical, prevention, recovery and peer perspectives, with clear responsibilities for turning relevant findings into action. For the global ISSUP community, these alerts offer lessons in preparedness while requiring careful consideration of local evidence, resources and service arrangements. Staying informed through trusted sources and sharing practical responses through ISSUP can help translate emerging knowledge into safer care and more responsive support for individuals, families and communities.

Abstract Importance National-level data are limited on the long-term costs and outcomes of integrating smoking cessation interventions into lung cancer screening (LCS) programs in the US. Objective To evaluate the cost-effectiveness of...

The Maine Nursing Preceptor Education Program registration is now open. Learners from across the globe are welcome. This fall program is fully virtual. Learners will complete 7 synchronous on demand modules followed by two live, virtual...

It’s been more than 50 years since the United States launched a “war on drugs.” History has demonstrated the ineffectiveness of “tough-oncrime” drug-use policies, including laws requiring mandatory minimum sentencing for possession of...

Introduction: For adults involved with the criminal justice system who are reentering their communities postincarceration, there is a large need for community-based substance use treatment. Little is known, however, about the types...