According to the 2022 World Drug Report, the non-medical use of opioids like fentanyl poses substantial risks to global health. Opioids remain the most lethal group of psychoactive substances, accounting for two-thirds of deaths related...
Source: Chhatwal J, Mueller PP, Chen Q, et al. Estimated Reductions in Opioid Overdose Deaths With Sustainment of Public Health Interventions in 4 US States. JAMA Netw Open. 2023;6(6):e2314925. doi:10.1001/jamanetworkopen.2023.14925 Key Points Question What is the association of sustaining public...
Fuente: https://nida.nih.gov/es/download/20630/el-fentanilo-drugfacts.pdf El fentanilo es un fuerte opioide sintético similar a la morfina, pero entre 50 y 100 veces más potente. Es un fármaco recetado que a veces también se usa en forma ilegal. Al igual que la morfina, por lo general se receta a...
Source: National Institute on Drug Abuse; National Institutes of Health; U.S. Department of Health and Human Services. Fentanyl is a powerful synthetic opioid that is similar to morphine but is 50 to 100 times more potent. It is a prescription drug that is also made and used illegally. Like morphine...
Na quinta-feira, 1º de junho, a OMS lançou o Repositório de Informações do Comitê de Especialistas em Dependência de Drogas (ECDD), que fornece aos profissionais de saúde e especialistas em políticas de drogas um único banco de dados pesquisável para acessar livremente todos os relatórios técnicos sobre mais de 450 substâncias revisadas pelo ECDD.
Source: Snowdon, J., & Choi, N. (2022). Unanticipated Changes in Drug Overdose Death Rates in Canada During the Opioid Crisis. International journal of mental health and addiction, 1–19. Advance online publication. https://doi.org/10.1007/s11469-022-00932-9
Source: Marel, C., Wilson, J., Darke, S., Ross, J., Slade, T., Haber, P. S., Haasnoot, K., Visontay, R., Keaveny, M., Tremonti, C., Mills, K. L., & Teesson, M. (2023). Patterns and Predictors of Heroin Use, Remission, and Psychiatric Health Among People with Heroin Dependence: Key Findings from the...
Hoy, la Administración de Alimentos y Medicamentos de los Estados Unidos (FDA, por sus siglas en inglés) aprobó la inyección subcutánea (para uso por debajo de la piel) de Brixadi (buprenorfina) de liberación prolongada para tratar el trastorno por consumo de opioides (OUD, por sus siglas en inglés) de moderado a grave. Brixadi está disponible en dos formulaciones, una inyección semanal...
Today, the U.S. Food and Drug Administration approved Brixadi (buprenorphine) extended-release injection for subcutaneous use (under the skin) to treat moderate to severe opioid use disorder (OUD). Brixadi is available in two formulations, a weekly injection that can be used in patients who have started treatment with a single dose of a transmucosal buprenorphine product or who are already being treated with buprenorphine, and...
Source: https://store.samhsa.gov/sites/default/files/pep23-02-01-002.pdf This Advisory outlines how healthcare providers (i.e., obstetrician-gynecologists [OB-GYNs], primary care physicians, and other professionals who treat pregnant people) can take an active role in supporting the health of...
Source: Taylor EA, Cantor JH, Bradford AC, Simon K, Stein BD. Trends in Methadone Dispensing for Opioid Use Disorder After Medicare Payment Policy Changes. JAMA Netw Open. 2023;6(5):e2314328. doi:10.1001/jamanetworkopen.2023.14328 Key Points Question Did rates of methadone dispensing for opioid use...
Source: Jakubowski, A., Singh-Tan, S., Torres-Lockhart, K. et al. Hospital-based clinicians lack knowledge and comfort in initiating medications for opioid use disorder: opportunities for training innovation. Addict Sci Clin Pract 18, 31 (2023). https://doi.org/10.1186/s13722-023-00386-x Abstract...
Degenhardt, L., Clark, B., Macpherson, G., Leppan, O., Nielsen, S., Zahra, E., ... & Farrell, M. (2023). Buprenorphine versus methadone for the treatment of opioid dependence: a systematic review and meta-analysis of randomised and observational studies. The Lancet Psychiatry.
Resumo
Fundo
A dependência de opioides está associada a encargos sociais e de saúde substanciais, e o tratamento com agonistas opioides (ACO) é altamente eficaz na melhoria de múltiplos desfechos para as pessoas que recebem esse tratamento. Metadona e buprenorfina são medicamentos comuns fornecidos como ACO. Nosso objetivo foi examinar a buprenorfina comparada à metadona no tratamento da dependência de opioides em uma ampla gama de desfechos primários e secundários.
Métodos
Os autores realizaram uma revisão sistemática e metanálise de estudos comparando o tratamento com buprenorfina ou...
Source: Onuoha, E. N., Leff, J. A., Schackman, B. R., McCollister, K. E., Polsky, D., & Murphy, S. M. (2021). Economic evaluations of pharmacologic treatment for opioid use disorder: a systematic literature review. Value in Health, 24(7), 1068-1083. Highlights There is new evidence on buprenorphine...
The International Research Conference Aims and Objectives
The International Research Conference is a federated organization dedicated to bringing together a significant number of diverse scholarly events for presentation within the confere...
Ponente: Dr. Carlos Galicia Galicia Los objetivos del seminario son conocer el fentanilo de uso médico y diferenciarlo del producido clandestinamente. Además, presentar los fundamentos neurobiológicos del consumo compulsivo de fentanilo.
