A Pioneer in Neurology and Neuro-Ophthalmology
the ISSUP community honors the life and legacy of Dr. Paul N. Hoffman, Professor Emeritus of Neurology and Ophthalmology at Johns Hopkins Medicine, who passed away on October 24, 2025, at the age of 78.
For over forty years, Dr. Hoffman was a leading voice in neuroscience — known globally for his pioneering research on axonal transport and neurofilament biology. His work transformed the world’s understanding of how nerve cells grow, function, and fail under disease, injury, or toxic exposure.
His research profoundly influenced how we approach neurological disorders linked to substance use, including neurotoxicity, peripheral neuropathy, and neurodegeneration. By uncovering how neurons’ internal architecture determines their strength and communication, Dr. Hoffman provided essential insight into the mechanisms by which substance misuse and chemical injury disrupt neural health.