Trivedi MH, et al. Trial of Bupropion and Naltrexone in Methamphetamine Use Disorder(link is external). New England Journal of Medicine. January 14, 2020.
A combination therapy of injectable naltrexone and oral bupropion was found in a randomized clinical trial to improve outcomes for patients with methamphetamine use disorder. This is important because there are no widely approved medication regimens to treat methamphetamine use disorder.