Psilocybin in the Treatment of Cocaine Use Disorder A Randomized Clinical Trial

Source:

Hendricks PS, Lappan SN, Shelton RC, et al. Psilocybin in the Treatment of Cocaine Use Disorder: A Randomized Clinical Trial. JAMA Netw Open. 2026;9(5):e2611029. doi:10.1001/jamanetworkopen.2026.11029

Key Points

Question  Does psilocybin combined with psychotherapy elicit abstinence from cocaine in people with cocaine use disorder relative to active placebo plus psychotherapy?

Findings  In this randomized clinical trial of 40 adults with cocaine use disorder, a single (25 mg per 70 kg of body weight) dose of psilocybin with manualized psychotherapy resulted in a higher percentage of cocaine abstinent days, a greater likelihood of complete cocaine abstinence, and a reduced risk of cocaine lapse through 180 days after end of treatment as compared with placebo with the same manualized psychotherapy.

Meaning  These findings suggest psilocybin shows promise as a novel treatment for cocaine use disorder.