TUSI Valve: Echocardiographic and Pathologic Correlates of a Novel Drug-Induced Valvular Disease—a Case Series

Source: 

Vasquez-Rodriguez, J. F., Lemus-Barrios, G., Rangel-Rivera, D., Garnica-Sepulveda, V., Avila, Y., Medina-Mur, R., ... & Dueñas-Criado, K. (2026). TUSI Valve: Echocardiographic and Pathologic Correlates of a Novel Drug-Induced Valvular Disease—a Case Series. CASE.

Highlights

•TUSI ("pink cocaine") use may cause serotonin-mediated drug-induced valvular disease.

•Echocardiography shows reproducible thickening and restricted atrioventricular valve motion.

•Histology reveals myxoid degeneration without inflammatory infiltrate.

•Young patients with unexplained regurgitation require drug-use screening.

•Synthetic drug use poses emerging cardiovascular risks needing attention.