Addiction

Abstract Cocaine exerts its behavioral stimulant effects by facilitating synaptic actions of neurotransmitters such as dopamine and serotonin. It is also neurotoxic and broadly cytotoxic, leading to overdose deaths. We demonstrate that the...

Working with mice, researchers at Johns Hopkins have contributed significant new evidence to support the idea that high doses of cocaine kill brain cells by triggering overactive autophagy, a process in which cells literally digest their...

Summary What is already known about this topic? Fentanyl has a growing presence in the illicit drug market and is involved in an increasing proportion of opioid overdose deaths. What is added by this report? Approximately two thirds of...

The social media quit-smoking intervention – Tweet2Quit – sends automated daily communications to private self-help groups, encouraging high-quality peer-to-peer discussions online. It is very low cost and has a potential global reach. A...

One of our selection of hot topics, analyses of important issues which sometimes generate heated debate. Programmes distributing the opiate overdose antidote naloxone have become the great new hope for curbing the rise in drug-related...