safety

World Patient Safety Day

Global Campaign,

In May 2019, the 72nd World Health Assembly endorsed the establishment of World Patient Safety Day to be observed annually on the 17th of September.

The main objective of World Patient Safety Day is to raise global awareness about patient safety and encourage global solidarity and action.

Effectiveness Bank Analysis: “Game-Changer” Opiate Addiction Medication Proves Effective in US Trial

Citation
Lancet: 2019, 393, p. 778-790.
Publication Date

Medication of the type heralded as a possible “game-changer” by one of the UK’s leading addiction treatment clinicians and researchers proved its worth in a US placebo-controlled trial. Buprenorphine injections with effects lasting a month are now available in the UK, offering a new option for treating dependence on heroin and allied drugs.

Effectiveness Bank Analysis: UPDATED Long-Acting Buprenorphine an Advance on Daily Doses

Citation
JAMA Internal Medicine: 2018, 178(6), p. 764-773.
Publication Date

*Updated with UK licensing information and advice released in February 2019 by the National Institute for Health and Care Excellence*

What could prove a technical advance in the medication-based treatment of dependence on heroin and allied drugs was rigorously tested and partially vindicated among hundreds of patients at over 30 US clinics.

A Double Blind, Placebo Controlled Trial of Modafinil for the Treatment of Cocaine Dependence without Co-Morbid Alcohol Dependence

Citation
Drug and Alcohol Dependence: 2015, 155, p. 105-110.
Publication Date

Like methadone for heroin dependence, modafinil is an oral medication with similar effects to cocaine but milder, slower in onset and longer-acting - properties which might help plug the gap in effective pharmacotherapies for dependence on cocaine/crack. This trial found it promoted abstinence from cocaine, but others have not, and side effects are a concern.

Effectiveness Bank Analysis: French Committee Says Risks of Baclofen Outweigh Benefits in Alcohol Treatment

*Updated* Our commentary on the first trial to rigorously test high-dose baclofen to treat dependent drinking has been updated with the release on 24 April 2018 of an opinion on the balance between safety and benefits from a scientific committee set up by France’s medicines regulator to help decide on an application to market the drug.

Methadone Induction in Primary Care for Opioid Dependence: A Pragmatic Randomized Trial

Citation
PLoS ONE: 2014, 9(11): e112328.
Publication Date

From France the first study to randomly allocate patients to start methadone maintenance either in primary care or at a specialist centre found primary care more attractive to patients and no less safe or effective at reducing street-opioid use and promoting engagement and retention.

Supervised Dosing with a Long-Acting Opioid Medication in the Management of Opioid Dependence

Citation
Cochrane Database of Systematic Reviews: 2017, Issue 4. Art. No.: CD011983
Publication Date

Trials challenge the need for the widely accepted policy of making opioid-dependent patients take their methadone or other opioid substitutes at the clinic or pharmacy, but ‘no difference’ findings may be due to the limitations of the research.