reward

How does MDMA Kill?

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MDMA (Methylenedioxymethamphetamine) is a synthetic drug that alters mood and perception (awareness of surrounding objects and conditions). MDMA was initially a common nightlife drug, but it affects a broader range of people.

Mindfulness-Based Treatment of Addiction: Current State of the Field and Envisioning the Next Wave of Research

Citation
Garland EL, Howard MO. (2018). Mindfulness-based treatment of addiction: current state of the field and envisioning the next wave of research. Addict Sci Clin Pract 13:14 https://doi.org/10.1186/s13722-018-0115-3
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Abstract

Contemporary advances in addiction neuroscience have paralleled increasing interest in the ancient mental training practice of mindfulness meditation as a potential therapy for addiction. In the past decade, mindfulness-based interventions (MBIs) have been studied as a treatment for an array addictive behaviors, including drinking, smoking, opioid misuse, and use of illicit substances like cocaine and heroin.

On the Physiology of Jouissance: Interpreting the Mesolimbic Dopaminergic Reward Functions from a Psychoanalytic Perspective

Citation
Bazan A and Detandt S (2013) On the physiology of jouissance: interpreting the mesolimbic dopaminergic reward functions from a psychoanalytic perspective. Front. Hum. Neurosci. 7:709. doi: 10.3389/fnhum.2013.00709
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Jouissance is a Lacanian concept, infamous for being impervious to understanding and which expresses the paradoxical satisfaction that a subject may derive from his symptom.

Neural Mechanisms of Extinguishing Drug and Pleasant Cue Associations in Human Addiction

Citation
Konova, A. B., Parvaz, M. A., Bernstein, V., Zilverstand, A., Moeller, S. J., Delgado, M. R., Alia-Klein, N., and Goldstein, R. Z. (2017) Neural Mechanisms of Extinguishing Drug and Pleasant Cue Associations in Human Addiction: Role of the VMPFC. Addiction Biology, doi: 10.1111/adb.12545.
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Abstract

The neurobiological mechanisms that underlie the resistance of drug cue associations to extinction in addiction remain unknown. Fear extinction critically depends on the ventromedial prefrontal cortex (VMPFC). Here, we tested if this same region plays a role in extinction of non-fear, drug and pleasant cue associations. Eighteen chronic cocaine users and 15 matched controls completed three functional MRI scans.