Combined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders A Systematic Review and Meta-analysis
Ray LA, Meredith LR, Kiluk BD, Walthers J, Carroll KM, Magill M. Combined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020;3(6):e208279. doi:10.1001/jamanetworkopen.2020.8279
Question Is cognitive behavioral therapy associated with improved outcomes for alcohol and other substance use disorders in the context of pharmacotherapy for addiction?
Findings This systemic review and meta-analysis including 30 studies found that combined cognitive behavioral therapy and pharmacotherapy was associated with increased benefit compared with usual care and pharmacotherapy. Cognitive behavioral therapy did not perform better than another evidence-based modality in this context or as an add-on to combined usual care and pharmacotherapy.
Meaning These findings suggest that best practices in addiction treatment should include pharmacotherapy plus cognitive behavioral therapy or another evidence-based therapy, rather than usual clinical management or nonspecific counseling services.