Pharmacological Interventions

Abstract It has long been known that individuals will engage in voluntary inhalation of volatile solvents for their rewarding effects. However, research into the neurobiology of these agents has lagged behind that of more commonly misused...

It is well documented that people with severe mental health issues are more likely to smoke compared to the general population. Smoking reduces physical wellbeing and is a key modifiable risk factor for health inequality. Despite this...

Abstract Background Cannabis, cannabinoids and endocannabinoids are heavily investigated topics with many articles published every year. We aimed to identify the 100 most cited manuscripts among the vast literature and analyze their...

ABSTRACT Background: People with severe substance use disorders require long-term rehabilitative care after the initial treatment. There is, however, a deficit in the availability of such care. This may be due both to inadequate medical...

Key Points Question: How does smoked and vaporized cannabis acutely influence subjective drug effects, cognitive and psychomotor performance, and cardiovascular measures in healthy adults who infrequently use cannabis (>30 days since last...

Key Points Question: What are the current trends in frequency and costs of amphetamine-related hospitalizations in the United States? Findings: In this cross-sectional study of approximately 1.3 million amphetamine-related US...

The endocannabinoid system is widespread throughout the central nervous system and its type 1 receptor (CB1) plays a crucial role in preventing the neurotoxicity caused by activation of glutamate N-methyl-D-aspartate receptors (NMDARs)...

ABSTRACT BACKGROUND Whether financial incentives, pharmacologic therapies, and electronic cigarettes (e-cigarettes) promote smoking cessation among unselected smokers is unknown. METHODS We randomly assigned smokers employed by 54 companies...

Glioblastoma (GBM) is the most malignant brain tumor and one of the deadliest types of solid cancer overall. Despite aggressive therapeutic approaches consisting of maximum safe surgical resection and radio-chemotherapy, more than 95% of...