Pharmacological Interventions

Abstract Extensive 3′ alternative splicing of the mu opioid receptor gene OPRM1 creates multiple C-terminal splice variants. However, their behavioral relevance remains unknown. The present study generated 3 mutant mouse models with...

Abstract Objectives: Our study aimed to evaluate the effectiveness of general practitioners’ (GPs’) smoking cessation support (SCS). Study design: We carried out a cross-sectional study between February and April 2016. Setting and...

Cigarette smoking damages just about every organ in the body and reduces overall health. Even with the prevalence of accessible nicotine replacement therapies and behavioral counseling, there remains a need for alternative therapies to...

Adenosine receptors (AR) are a family of G-protein coupled receptors, comprised of four members, named A1, A2A, A2B, and A3 receptors, found widely distributed in almost all human body tissues and organs. To date, they are known to...

Yanhui Liao Introduction: Chronic use of both Ketamine (“K powder”) and methamphetamine (MA, “ice”) can induce psychiatric symptoms. This study aimed at exploring drug-induced psychiatric symptoms in chronic ketamine users and MA users...

Rationale The goal of this guideline is to improve the quality of care and treatment outcomes for patients with alcohol use disorder (AUD), as defined by DSM-5 (American Psychiatric Association 2013). The guideline focuses specifically on...

Inclusion Health is a framework for action that helps find ways of improving the health and well-being for socially excluded groups. These populations, who have in common adverse life experiences and risk factors, such as poverty and...

In 2013 nalmefene was authorised for moderating drinking among patients not in need of detoxification, extending pharmacotherapy to less dependent drinkers. Though uniquely authorised for this purpose, this review found other (and probably...

SUMMARY Drug addiction is one of the most important health problems worldwide. This pathology results in the death of about 500,000 individuals annually around the globe. Despite this scenario, the development of effective drug therapies...