Supply & Market Disruption

Supply and market disruption refers to coordinated strategies aimed at reducing the production, trafficking, distribution, and availability of illicit substances. These strategies often involve law enforcement, regulatory controls, border management, and financial investigations designed to disrupt drug trafficking networks and weaken illicit drug markets. By targeting supply chains and market dynamics, these efforts aim to reduce the availability of drugs, increase the risks and costs associated with illegal production and distribution, and contribute to broader efforts to reduce substance-related harms. Effective supply and market disruption typically operates alongside public health, prevention, treatment, and recovery responses as part of a comprehensive approach to substance use. 

Synthetic cannabinoids: Reflections from Mauritius

Community update
During a recent engagement in Mauritius, I had the opportunity to hear the National Agency for Drug Control (NADC) present the National Drug Control Master Plan 2026–2030 and to share the suite of resources available through ISSUP. This...
Mauritius National Agency for Drug Control (NADC) present the National Drug Control Master Plan 2026–2030

Carfentanil Detected in Counterfeit Tablets and Powders: What the Substance Use Workforce Should Know

Community update
A new health alert reports carfentanil in counterfeit “M30” tablets and powders seized at the United States Southwest border. Carfentanil is an extremely potent synthetic opioid, and some tablets contained it without any fentanyl. The findings highlight how the appearance of an illicit tablet or powder cannot reliably indicate its contents or strength. Prevention, treatment and recovery professionals should reinforce overdose awareness, naloxone access and timely connections to care. Law enforcement, laboratories and public health partners should follow safe handling protocols, test comprehensively and share emerging drug market information quickly.
CFSRE NPS Discovery programme April 2026 Synthetic Opioid Alert

Drug production and precursors — EUDA ongoing activities

Website
The European Union Drugs Agency (EUDA) continues to monitor illicit drug production and precursor chemicals across Europe to improve understanding of how drug markets are evolving. Production within the European Union is primarily focused...
EUDA

2025 National Drug Threat Assessment (NDTA) - Drug Enforcement Administration (DEA)

Report
The U.S. Drug Enforcement Administration (DEA) has released its 2025 National Drug Threat Assessment (NDTA), providing an overview of the threats posed by illicit drugs and the transnational criminal organizations involved in their production and trafficking. The report highlights the continuing impact of synthetic drugs, particularly fentanyl and methamphetamine, on public health, public safety, and national security.
The Drug Enforcement Administration (DEA)

UN Toolkit on Synthetic Drugs

Toolkit
The UN Toolkit on Synthetic Drugs is a practical online resource coordinated by UNODC that brings together tools, guidance, and operational resources from across the UN system to support responses to the global synthetic drug problem...