Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice

Source:

Day, S. M., Gironda, S. C., Clarke, C. W., Snipes, J. A., Nicol, N. I., Kamran, H., ... & Macauley, S. L. (2023). Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice. Neurobiology of Disease, 177, 105967.

Highlights

•-Chronic ethanol exposure increases brain atrophy in APP/PS1 mice.

•-Chronic ethanol exposure increases the number of amyloid plaques in APP/PS1 brains.

•-Chronic ethanol exposure dysregulates metabolism in APP/PS1 mice.

•-Chronic ethanol exposure alters anxiety- and dementia-related behaviors in APP/PS1 mice.

•-Acute ethanol increases interstitial fluid (ISF) amyloid-β 40 (Aβ40) but not Aβ42 levels in APP/PS1 mice during withdrawal