Clinical Outcomes and Healthcare Perspectives on Adolescent Kratom Use in the Czech Republic: A Study Protocol

ABSTRACT: Kratom (Mitragyna speciosa), a plant native to Southeast Asia, has gained global popularity due to both its dose-dependent stimulant and sedative effects. This has raised concerns, particularly around adolescent use, as regular consumption can lead to dependence and withdrawal symptoms. In the Czech Republic, kratom is reportedly used alongside cannabis among adolescents. However, there is limited clinical data on the impact of kratom dependence within this demographic. This study aims to address this gap by exploring adolescent kratom use from the clinical and healthcare policy perspectives. It employs a mixed-methods approach, comprising a systematic review of existing literature, a pilot study involving healthcare professionals, and retrospective clinical case reports of adolescent kratom users from an outpatient addiction clinic. The systematic review will synthesise knowledge on kratom’s effects and treatment strategies, while the pilot study will explore healthcare workers’ experiences and challenges in managing adolescent kratom use. The case reports will provide detailed insights into clinical presentations and treatment outcomes. By integrating these perspectives, the study seeks to improve understanding of adolescent kratom use and dependence, and inform the development of targeted, evidence-based treatment strategies, ultimately contributing to enhanced healthcare practices and policy development for addressing kratom use in this vulnerable population.