Does Following Research-Derived Practice Guidelines Improve Opiate-Dependent Patients’ Outcomes under Everyday Practice Conditions? Results of the Multisite Opiate Substitution Treatment Study

Journal of Substance Abuse Treatment: 2008, 34(2), p. 173-179.
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Two sets of US methadone clinics selected for high versus low adherence to clinical guidelines provided evidence that in everyday practice, the recommended high doses and intensive psychosocial services really do reduce substance use and may have wider benefits.