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webinar United States
Jose Luis Vazquez Martinez

Scientists from NIDA’s Intramural Labs discuss what we can learn from methadone, a drug used to manage opioid addiction that does not have euphoric effects as strong as many other opioids.

Jose Luis Vazquez Martinez

La naloxona salva vidas. Este video explica cuándo se usa la naloxona, cómo se administra y cómo funciona. Haga clic en "VER MÁS" para obtener más información. Los Institutos Nacionales de la Salud de los EE. UU.

Jose Luis Vazquez Martinez

Air date: Tuesday, April 17, 2018, 4:00:00 PM

Description: Demystifying Medicine 

The Effects of Oxytocin on Withdrawal, Craving and Stress Response in Heroin-Dependent Patients

According to the World Drug Report opioids are the most harmful drug type, accounting for 70% of the adverse health impacts associated with drug use disorders worldwide. Treatment typically focusses on controlling withdrawal, preventing cravings and ultimately relapse. Maintenance treatments are used for chronic opioid-dependent patients who cannot achieve abstinence.

 A recent randomised, double-blind trial has examined the effectiveness of oxytocin, a neuropeptide that is produced by the hypothalamus, as part of the treatment of addiction. The researchers analysed the effect of oxytocin on withdrawal, craving, anxiety and cortisol and dehydroepiandrosterone sulphate (DHEAS) blood level in heroin-dependent 58 male patients.

Results from the study show:

  • Administration of a single dose of oxytocin significantly improved craving scores as described through self-report measures.
  • Acute administration of oxytocin significantly reduced the withdrawal symptoms.
  • Oxytocin therapy did not significantly affect the mean differences of the anxiety scores compared with the placebo group
  • In comparison with the placebo group, the oxytocin treatment significantly decreased serum cortisol level (a hormone particularly involved in the stress response).

The researchers suggest oxytocin increases resilience against addiction and supports social bonding and attachment-related information being consolidated in internal working models. These results indicate that oxytocin has the potential to reduce craving and withdrawal symptoms in heroin-dependent patients.

Jose Luis Vazquez Martinez

The opioid epidemic has significantly penetrated the criminal justice (CJ) system. This brief provides guidance to state governments on increasing the availability of evidence-based MAT in CJ settings.

Webinar: An Overview of CDC’s Enhanced State Opioid Overdose Surveillance (ESOOS) Program

Event Date
United States

March 5th 11:00am-12:00pm

Drs. Kariisa and Roehler will provide an overview of CDC’s Enhanced State Opioid Overdose Surveillance (ESOOS) program. We will highlight the three key strategies CDC is employing to improve opioid-related overdose surveillance.

Mbabazi Kariisa is a Health Scientist in the Division of Unintentional Injury Prevention in CDC’s National Center for Injury Prevention and Control and serves as a science officer focusing on mortality-related activities for CDC’s Enhanced State Opioid Overdose Surveillance program. Prior to joining NCIPC, she worked as an injury epidemiologist for the Ohio Department of Health in Columbus. Mbabazi receiver her PhD in Epidemiology from The Ohio State University and an MPH in International Health from the University of Michigan.

Douglas Roehler, PhD, MPH, is a Health Scientist on the overdose epidemiology and surveillance team in CDC’s National Center for Injury Prevention and Control, where he supports the morbidity activities for the CDC’s Enhanced State Opioid Overdose Surveillance (ESOOS). He completed a postdoctoral research fellowship at Rush University Medical Center in Chicago where he focused on child injury prevention. Doug received his doctoral degree from the University of Michigan School of Public Health.

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Jose Luis Vazquez Martinez

Nora Volkow, director of the National Institute on Drug Abuse, talks about the science of opioid addiction and treatment. (Taped: 04-21-16)


NIH has made the opioid epidemic a priority, launching a multi-institute effort to find scientific solutions to the crisis.

Jose Luis Vazquez Martinez

This Clinical Guide provides comprehensive, national guidance for optimal management of pregnant and parenting women with opioid use disorder and their infants.

Jose Luis Vazquez Martinez
portada de la guía

A pesar de que en México está disponible en tratam