cannabidiol

Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios

Englund, A., Oliver, D., Chesney, E. et al. Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios. Neuropsychopharmacol. (2022). https://doi.org/10.1038/s41386-022-01478-z
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Abstract

As countries adopt more permissive cannabis policies, it is increasingly important to identify strategies that can reduce the harmful effects of cannabis use. This study aimed to determine if increasing the CBD content of cannabis can reduce its harmful effects.

Examining the Profile of High-Potency Cannabis and its Association with Severity of Cannabis Dependence

Freeman, T. P., & Winstock, A. R. (2015). Examining the profile of high-potency cannabis and its association with severity of cannabis dependence. Psychological medicine, 45(15), 3181-3189.

Abstract

Background

Cannabis use is decreasing in England and Wales, while demand for cannabis treatment in addiction services continues to rise. This could be partly due to an increased availability of high-potency cannabis.

Method

Cannabidiol (CBD) Content in Vaporized Cannabis does not Prevent Tetrahydrocannabinol (THC)-induced Impairment of Driving and Cognition

Arkell, T.R., Lintzeris, N., Kevin, R.C. et al. Psychopharmacology (2019). https://doi.org/10.1007/s00213-019-05246-8
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Abstract

Background

The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC. It is possible then that cannabis containing equivalent CBD and THC will differentially affect driving and cognition relative to THC-dominant cannabis.

Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs

Dumitru CA, Sandalcioglu IE and Karsak M (2018) Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs. Front. Mol. Neurosci. 11:159. doi: 10.3389/fnmol.2018.00159
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Glioblastoma (GBM) is the most malignant brain tumor and one of the deadliest
types of solid cancer overall. Despite aggressive therapeutic approaches consisting of
maximum safe surgical resection and radio-chemotherapy, more than 95% of GBM
patients die within 5 years after diagnosis. Thus, there is still an urgent need to develop

Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin

Maggio N, Shavit Stein E and Segal M (2018) Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin. Front. Mol. Neurosci. 11:32. doi: 10.3389/fnmol.2018.00032
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Epilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope with epilepsy. We have studied the effects of cannabidiol (CBD) on the ability to produce long term potentiation (LTP) in stratum radiatum of CA1 region of the mouse hippocampus. Exposure to seizure-producing pilocarpine reduced the ability to generate LTP in the slice.