cannabinoids

Correlates of treatment engagement and client outcomes: results of a randomised controlled trial of nabiximols for the treatment of cannabis use disorder

Mills, L., Dunlop, A., Montebello, M. et al. Correlates of treatment engagement and client outcomes: results of a randomised controlled trial of nabiximols for the treatment of cannabis use disorder. Subst Abuse Treat Prev Policy 17, 67 (2022).
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Introduction 

There is increasing interest and evidence for the use of cannabinoid medications in the treatment of cannabis use disorder, but little examination of the correlates of successful treatment.

Associations Between Canada's Cannabis Legalization and Emergency Department Presentations for Transient Cannabis-Induced Psychosis and Schizophrenia Conditions: Ontario and Alberta, 2015–2019

Callaghan, R. C., Sanches, M., Murray, R. M., Konefal, S., Maloney-Hall, B., & Kish, S. J. (2022). Associations Between Canada's Cannabis Legalization and Emergency Department Presentations for Transient Cannabis-Induced Psychosis and Schizophrenia Conditions: Ontario and Alberta, 2015–2019. The Canadian Journal of Psychiatry, 07067437211070650.
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Abstract

Objective

Cannabis legalization in many jurisdictions worldwide has raised concerns that such legislation might increase the burden of transient and persistent psychotic illnesses in society. Our study aimed to address this issue.

The Synaptic Interactions of Alcohol and the Endogenous Cannabinoid System

Wolfe, S. A., Vozella, V., & Roberto, M. (2022). The synaptic interactions of alcohol and the endogenous cannabinoid system. Alcohol Res, 42(1).
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ABSTRACT

PURPOSE: A growing body of evidence has implicated the endocannabinoid (eCB) system in the acute, chronic, and withdrawal effects of alcohol/ethanol on synaptic function. These eCB-mediated synaptic effects may contribute to the development of alcohol use disorder (AUD). Alcohol exposure causes neurobiological alterations similar to those elicited by chronic cannabinoid (CB) exposure.

Variation in Cannabinoid Metabolites Present in the Urine of Adults Using Medical Cannabis Products in Massachusetts

Gilman JM, Schmitt WA, Wheeler G, et al. Variation in Cannabinoid Metabolites Present in the Urine of Adults Using Medical Cannabis Products in Massachusetts. JAMA Netw Open. 2021;4(4):e215490. doi:10.1001/jamanetworkopen.2021.5490
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The findings of this cohort study are consistent with those of a study of cannabis products purchased in California and Washington, in which more than one-half of products were incorrectly labeled.

Cannabinoid Exposure in Rat Adolescence Reprograms the Initial Behavioral, Molecular, and Epigenetic Response to Cocaine

Scherma, M., Qvist, J. S., Asok, A., Shao-shan, C. H., Masia, P., Deidda, M., ... & Kandel, E. R. (2020). Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine. Proceedings of the National Academy of Sciences.
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Significance

The endocannabinoid system has a modulatory role in brain reward and cognitive processes. It has been hypothesized that repeated interference with endocannabinoid signaling (e.g., through abuse of cannabis or synthetic cannabinoids) can remodel the adolescent brain and make it respond differently to more addictive substances, such as cocaine.

25th NIDA International Forum

Hollywood, Florida, United States,

The National Institute on Drug Abuse (NIDA) International Forum fosters international cooperative research and the exchange of scientific information by drug abuse researchers. Held each June in conjunction with the annual scientific meeting of the College on Problems of Drug Dependence (CPDD), the Forum highlights the range and quality of drug abuse and addiction research conducted around the world.

Sex-Dependent Effects of in Utero Cannabinoid Exposure on Cortical Function

Bara, A., Manduca, A., Bernabeu, A., Borsoi, M., Serviado, M., Lassalle, O., ... & Trezza, V. (2018). Sex-dependent effects of in utero cannabinoid exposure on cortical function. eLife, 7, e36234.
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Abstract

Cannabinoids can cross the placenta, thus may interfere with fetal endocannabinoid signaling during neurodevelopment, causing long-lasting deficits. Despite increasing reports of cannabis consumption during pregnancy, the protracted consequences of prenatal cannabinoid exposure (PCE) remain incompletely understood.