cannabinoids

Cannabinoid Exposure in Rat Adolescence Reprograms the Initial Behavioral, Molecular, and Epigenetic Response to Cocaine

Citation
Scherma, M., Qvist, J. S., Asok, A., Shao-shan, C. H., Masia, P., Deidda, M., ... & Kandel, E. R. (2020). Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine. Proceedings of the National Academy of Sciences.
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Significance

The endocannabinoid system has a modulatory role in brain reward and cognitive processes. It has been hypothesized that repeated interference with endocannabinoid signaling (e.g., through abuse of cannabis or synthetic cannabinoids) can remodel the adolescent brain and make it respond differently to more addictive substances, such as cocaine.

25th NIDA International Forum

Hollywood, Florida, United States,

The National Institute on Drug Abuse (NIDA) International Forum fosters international cooperative research and the exchange of scientific information by drug abuse researchers. Held each June in conjunction with the annual scientific meeting of the College on Problems of Drug Dependence (CPDD), the Forum highlights the range and quality of drug abuse and addiction research conducted around the world.

Sex-Dependent Effects of in Utero Cannabinoid Exposure on Cortical Function

Citation
Bara, A., Manduca, A., Bernabeu, A., Borsoi, M., Serviado, M., Lassalle, O., ... & Trezza, V. (2018). Sex-dependent effects of in utero cannabinoid exposure on cortical function. eLife, 7, e36234.
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Abstract

Cannabinoids can cross the placenta, thus may interfere with fetal endocannabinoid signaling during neurodevelopment, causing long-lasting deficits. Despite increasing reports of cannabis consumption during pregnancy, the protracted consequences of prenatal cannabinoid exposure (PCE) remain incompletely understood.

Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs

Citation
Dumitru CA, Sandalcioglu IE and Karsak M (2018) Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs. Front. Mol. Neurosci. 11:159. doi: 10.3389/fnmol.2018.00159
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Glioblastoma (GBM) is the most malignant brain tumor and one of the deadliest
types of solid cancer overall. Despite aggressive therapeutic approaches consisting of
maximum safe surgical resection and radio-chemotherapy, more than 95% of GBM
patients die within 5 years after diagnosis. Thus, there is still an urgent need to develop

Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea

Citation
David W Carley, Bharati Prasad, Kathryn J Reid, Roneil Malkani, Hryar Attarian, Sabra M Abbott, Boris Vern, Hui Xie, Chengbo Yuan, Phyllis C Zee; Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea, Sleep, Volume 41, Issue 1, 1 January 2018, zsx184, https://doi.org/10.1093/sleep/zsx184
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Abstract

Study Objectives

Marijuana on the Mind? The Impact of Marijuana on Cognition, Brain Structure, and Brain Function, and Related Public Policy Implications

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Abstract

Although marijuana (MJ) has been used for thousands of years, the public’s opinion of MJ has shifted drastically over the past century, leaving many wondering about its potential risks and benefits. This article summarizes research detailing the impact of recreational MJ and related variables (frequency, magnitude, potency, and mode of MJ use) on cognition, brain structure, and brain function.