fentanyl

2025 National Drug Threat Assessment (NDTA) - Drug Enforcement Administration (DEA)

Report

The U.S. Drug Enforcement Administration (DEA) has released its 2025 National Drug Threat Assessment (NDTA), providing an overview of the threats posed by illicit drugs and the transnational criminal organizations involved in their...

The Drug Enforcement Administration (DEA)

Medetomidine in the U.S. Illegal Fentanyl Supply Increasing Risk for Overdose and Severe Withdrawal Syndrome

News

The Centers for Disease Control and Prevention (CDC), in conjunction with the White House Office of National Drug Control Policy (ONDCP), is issuing this Health Advisory to notify public health professionals, clinicians, laboratorians, and...

Buprenorphine initiation from fentanyl using low-dose intramuscular ketamine: a pilot study

Scientific article

11 February 2026

Abstract Background Buprenorphine is an effective medication for treating opioid use disorder but is underutilized partly due to patient apprehensiveness of the severe withdrawal symptoms it can induce when started, particularly by fentanyl...

Fentanyl in Cocaine: What New York Families Need to Know Right Now

News

26 November 2025

I’m seeing a rise in fentanyl-contaminated cocaine across New York City, Long Island, and the Hudson Valley. I share real cases, warning signs, and harm-reduction strategies families can use—including free 22-panel tests—to prevent fatal overdoses.

Seized cocaine, fentanyl, firearms, and equipment from NY AG Hudson Valley takedown.

The anomalous pharmacology of fentanyl

Scientific article

24 May 2021

Fentanyl is a key therapeutic, used in anaesthesia and pain management. It is alsoincreasingly used illicitly and is responsible for a large and growing number of opioidoverdose deaths, especially in North America. A number of factors have...

Synthetic Opioids: Navigating a Changing Landscape in the Treatment of Opioid Use Disorder

Guide

This 35-minute module focuses on how primary care providers can navigate the changing landscape of opioid use disorder in relation to synthetic opioids.

ISRAEL POLICE: Fentanyl Distribution Cases

News

1 June 2023

Attached: an article written by Superintendent Ilan Malka of ISRAEL POLICE on the subject of Fentanyl Distribution Cases published in WCO RILO WE INFO magazine - June 2023 edition.

Self-reported Xylazine Experiences: A Mixed-methods Study of Reddit Subscribers

Scientific article

10 August 2023

Abstract Objectives Xylazine is an α2-agonist increasingly prevalent in the illicit drug supply. Our objectives were to curate information about xylazine through social media from people who use drugs (PWUDs). Specifically, we sought to...

UNODC World Drug Report 2023 warns of converging crises as illicit drug markets continue to expand

Continued record illicit drug supply and increasingly agile trafficking networks are compounding intersecting global crises and challenging health services and law enforcement responses, according to the World Drug Report 2023 launched by the UN Office on Drugs and Crime (UNODC) today.

Fentanilo: un problema actual / Fentanyl: a current issue

21 June 2023

Washington D.C.

United States

According to the 2022 World Drug Report, the non-medical use of opioids like fentanyl poses substantial risks to global health. Opioids remain the most lethal group of psychoactive substances, accounting for two-thirds of deaths related directly to drugs, primarily overdoses. Additionally, fentanyl and its analogs were present in 90% of defined daily doses of synthetic opioids seized in 2020.